Safe4RAIL-2 is a project aimed at improving the safety and efficiency of the European railway system. It is framed within the European initiative Shift2Rail of Horizon 2020, whose objective is to deliver through railway research and innovation the capabilities to bring about the most sustainable, cost-efficient, high-performing, time driven, digital and competitive customer-centred transport mode for Europe. Safe4RAIL-2 takes as its baseline the results from previous projects such as Safe4RAIL, in which IKERLAN participated, where the main technologies and reference architectures were established.