Wall Street ends lower; S&P 500 in biggest three-day drop since January

NEW YORK (Reuters) - U.S. stocks fell on Monday with the S&P 500 posting its biggest three-day drop in two months, as investors bid down Internet stocks and rotated into defensive names to protect against further declines.

Internet stocks were among the day's biggest decliners with Amazon.com down 1.6 percent at $317.76 and Yahoo! Inc off 3.5 percent at $33.07. The Global X Social Media ETF which includes Groupon Inc and LinkedIn fell 2.5 percent.

The Nasdaq index <.IXIC> posted its worst three-day decline since November 2011.

But the biotechnology sector, which saw sharp declines in the past several sessions, ended higher with the Nasdaq biotech sector index <.NBI> up 0.5 percent at 2,367.94.

Selling pressure migrated to other sectors, with only defensives such as utilities <.SPLRCU> and consumer staples <.SPLRCS> in positive territory among the 10 major S&P sectors.

"This type of market behavior (buyers favoring defensive names) suggests investors are turning cautious again after the big gains in stocks during the past year," said Gary Thayer, chief macro strategist at Wells Fargo Advisors.

"We remain long-term positive on the U.S. economy and the U.S. stock market but expect increased volatility risk this spring and summer."

The CBOE Volatility index VIX <.VIX>, often used to gauge investor sentiment on Wall Street, jumped 11.5 percent to 15.56. The index usually moves inversely to the S&P 500.

Dish Network Corp was among the top decliners on the Nasdaq 100 <.NDX>, down 4.4 percent at $59.51.

The Dow Jones industrial average <.DJI> fell 166.84 points or 1.02 percent, to 16,245.87, the S&P 500 <.SPX> lost 20.05 points or 1.08 percent, to 1,845.04 and the Nasdaq Composite <.IXIC> dropped 47.973 points or 1.16 percent, to 4,079.753.

Pfizer Inc , down 3 percent to $31.20, added pressure to the Dow and S&P 500. The company's experimental breast cancer drug in a clinical trial nearly doubled the amount of time patients lived without their disease getting worse, but overall survival was not yet shown to be statistically significant, researchers said.

Earnings season gets under way this week, with results due from financials JPMorgan Chase & Co and Wells Fargo & Co , as well as retailer Bed, Bath & Beyond .

S&P 500 companies' first-quarter earnings are projected to have increased just 1.2 percent from a year ago, Thomson Reuters data showed. The forecast is down sharply from the start of the year, when growth was estimated at 6.5 percent.

A lackluster first-quarter earnings season hurt by a harsh winter could spark a pullback, some analysts said, with investors more optimistic for the second quarter.

Specialty pharmaceuticals company Mallinckrodt Plc agreed to buy drugmaker Questcor Pharmaceuticals Inc for about $5.6 billion to gain access to its multiple sclerosis drug, Acthar Gel. Questcor shares climbed 18.7 percent to $80.58 while Mallinckrodt dropped 2.5 percent to $60.95.

About 7.5 billion shares changed hands on U.S. exchanges, above the 6.6 billion average so far this month, according to data from BATS Global Markets.

(Reporting by Angela Moon; Editing by Nick Zieminski)

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