Biogen Idec Commences Mailing of Proxy Materials to Shareholders

Biogen Idec (Nasdaq: BIIB) today commenced the mailing of proxy

materials encouraging shareholders to vote at the company´s

June 19, 2008 Annual Meeting for four highly regarded and accomplished

individuals nominated for election by the Board of Directors. In the

proxy materials, shareholders are advised by the Board to reject the

three director nominees proposed by Carl Icahn.
In a letter to shareholders accompanying the proxy materials, Chairman

Bruce R. Ross and Chief Executive Officer James C. Mullen note that

three of the Board´s nominees, Cecil B.

Pickett, Ph.D., Lynn Schenk and Phillip A. Sharp, Ph.D., have

contributed as directors to the growth and success of the company, and

Stelios Papadopoulos, Ph.D., a new nominee, is an investment banker with

a distinguished career in biotechnology.
The letter emphasizes three critical points for shareholders to consider

in determining their vote:
1. The Biogen Idec Board, including the three directors up for

re-election, has a track record of delivering value, as evidenced by the

company´s consistently strong financial

results and stock performance exceeding the Amex Biotechnology Index

(BTK) by 26% in the four-plus years since the Biogen Idec merger (as of

May 2, 2008).
2. Each of the Board´s four nominees is

committed to creating significant value for all shareholders and will

continue to pursue all options to do so.
3. Mr. Icahn has consistently promoted a single-minded agenda to sell

the company. The company believes that electing his slate will impair

the company´s efforts to deliver and drive

shareholder value.
The letter cautions shareholders not to "jeopardize

your company´s continued growth by electing to

your Board an Icahn faction committed only to a sale of the company

regardless of whether that is in your best interests as a shareholder." Shareholders are asked to "elect your Board´s

nominees who are committed to creating value for all owners and who are

open to all options to create shareholder value."
The full letter to shareholders follows:
May 8, 2008
Dear Fellow Shareholder:
Your vote at the June 19, 2008 Annual Meeting is critically important to

the future of your investment in Biogen Idec.
As you may know, Carl Icahn has launched a proxy contest to get his

hand-picked representatives elected to the Biogen Idec Board of

Directors.
We strongly urge you to vote for the four highly regarded and

accomplished individuals nominated by your Board. Please use the WHITE proxy card to vote today "“ by telephone, by

Internet or by signing, dating and returning the enclosed WHITE proxy card.
It is important that you carefully consider these three critical points:
1. Your Board, including the three directors up for re-election, has a

track record of delivering value, as evidenced by your company´s

consistently strong financial results and stock performance exceeding

the Amex Biotechnology Index (BTK) by 26% in the four-plus years since

the Biogen Idec merger.1
2. Each of your Board´s four nominees is

committed to creating significant value for all shareholders and will

continue to pursue all options to do so.
3. Mr. Icahn has consistently promoted a single-minded agenda to sell

the company. Electing his slate will impair our efforts to deliver and

drive shareholder value.
A PROVEN TRACK RECORD OF DELIVERING VALUE
Your Board has an exceptional record of creating value for all

shareholders. The proof is in the results (see chart 1 in accompanying

multimedia).
Your Board´s superior leadership has

benefited all shareholders:

Your Board has delivered on the revenue and earnings goals set at the

time of the 2003 merger of Biogen, Inc. and IDEC Pharmaceuticals

Corp., generating 14% compound annual revenue growth and 22% compound

annual non-GAAP earnings growth.

In 2007, Biogen Idec generated nearly $3.2 billion in revenues.

In the first quarter of 2008, we reported revenues of $942 million, up

32% from the same period last year, and non-GAAP diluted earnings per

share (EPS) of $0.83, up 41%.

Your company has grown into a true industry leader. Since the merger

its value has grown by more than $7 billion to $18.3 billion as of May

2, 2008. The stock price outperformed the industry over this four-year

period, rising 86% compared to 68% for the BTK, the industry benchmark

index. In the past year, the business gained even greater momentum with

the stock price increasing an impressive 30%, while the BTK fell 9% (see

chart 2 in accompanying multimedia).
COMMITTED TO CREATING VALUE FOR ALL SHAREHOLDERS
Your Board has nominated four highly regarded and accomplished

individuals. Cecil B. Pickett, Ph.D., Lynn Schenk and Phillip A. Sharp

Ph.D., have contributed as directors to the growth and success of your

company. Stelios Papadopoulos, Ph.D., a new nominee, is an investment

banker with a distinguished career in the biotechnology sector.
Each of these individuals is committed to building on the strong growth

momentum already underway at Biogen Idec. They, like the rest of your

Board, are open to all opportunities for continuing to build value and

will objectively evaluate all options for maximizing your investment in

Biogen Idec. That commitment includes considering a potential sale as

circumstances evolve.
Your Board conducted a thorough sale process last fall that resulted in

no offers to buy the company. This Board is focused on executing a

comprehensive strategic growth plan that does not rely on any single

event or single approach; rather its components include:

Growing the sales and markets for our approved products;

Advancing our robust product pipeline;

Continuing disciplined business-development efforts to enrich our

pipeline and product portfolio; and

Attracting and retaining top professionals, including medical and

scientific talent.

By focusing on executing our strategic plan and driving the business

forward, we intend to continue to grow revenues at a 15% compound annual

growth rate (CAGR) and non-GAAP diluted EPS at a 20% CAGR through 2010.
Our goals for 2010 are supported by our 2008 financial guidance, which

we raised on April 23 when we reported our outstanding first-quarter

results:

Total revenue growth of 20% over 2007;

Non-GAAP diluted EPS in the range of $3.25-$3.45, representing growth

consistent with our stated goal of achieving 20% non-GAAP EPS compound

growth through 2010.

WE BELIEVE ELECTING THE ICAHN FACTION WILL HARM SHAREHOLDER VALUE
After the receipt last fall of an offer for the company from Mr. Icahn

as well as other expressions of interest, the Board of Directors

determined it was appropriate to explore whether the sale of the company

could generate greater value for shareholders than continuing to execute

upon our business strategy as an independent company. Mr. Icahn chose

not to participate in the process.
Your Board, in consultation with management and independent advisors

developed and executed a sale process that was professional, objective

and thorough. In the end, market conditions were not right, and

definitive bids for the company were not made.
Despite those facts, Mr. Icahn and his nominees insist on advancing a

single-minded agenda of forcing a sale of the company. In light of the

results of the recent sale process, your Board has concerns about the

consequences of restarting a sale process at this time.
Pursuing such a single-minded strategy, especially within the six-month

timeframe that Mr. Icahn has publicly specified, poses a very real risk

to shareholder value and the strong growth momentum currently underway

at your company. The ongoing uncertainty of putting a perpetual "for

sale" sign on the company would harm our

efforts to attract and retain top professionals "“ including top medical and scientific talent "“ and our ability to execute strategic partnerships and licensing

agreements.
Over more than two decades, Mr. Icahn has waged a long string of proxy

fights, largely against underperforming companies. In stark contrast

Biogen Idec has been delivering strong performance and your company´s

prospects for growth have never been better. Even Mr. Icahn has said

that Biogen Idec is a "great company," and we agree.
Do not jeopardize your company´s continued

growth by electing to your Board an Icahn faction committed only to a

sale of the company regardless of whether that is in your best interests

as a shareholder.
We urge you to elect your Board´s nominees

who are committed to creating value for all owners and who are open to

all options to create shareholder value.
Please vote today to re-elect Cecil B. Pickett, Ph.D., Lynn Schenk and

Phillip A. Sharp, Ph.D., and elect Stelios Papadopoulos, Ph.D., to your

Board of Directors "“ by telephone, by

Internet or by signing, dating and returning the enclosed WHITE proxy card.
Sincerely

Bruce Ross, Chairman James Mullen, Chief Executive Officer
Your Vote Is Important, No Matter How Many Or How Few Shares You Own.
If you have questions about how to vote your shares, or need additional

assistance, please contact the firm assisting us in the solicitation of

proxies:
INNISFREE M&A INCORPORATED|Stockholders Call

Toll-Free: (877) 750-5836Banks and Brokers Call Collect:

(212) 750-5833
IMPORTANT
We urge you NOT to sign any Gold proxy card sent to you by The Icahn

Parties. If you have already done so, you have every legal right to

change your vote by using the enclosed WHITE proxy card to vote TODAY"” by telephone, by Internet, or by signing, dating and returning the WHITE proxy card in the postage-paid envelope provided.
Safe Harbor
This letter to shareholders contains forward-looking statements, which

appear under the heading "Committed to

Creating Value for All Shareholders" above.

Forward-looking statements are subject to risks and uncertainties that

could cause actual results to differ materially from that which we

expect. Important factors that could cause our actual results to differ

include our continued dependence on our two principal products, AVONEX

and RITUXAN, the uncertainty of success in commercializing other

products including TYSABRI, the occurrence of adverse safety events with

our products, the consequences of the nomination of directors for

election to our Board by an activist shareholder, the failure to execute

our growth strategy successfully or to compete effectively in our

markets, our dependence on collaborations over which we may not always

have full control, possible adverse impact of government regulation and

changes in the availability of reimbursement for our products, problems

with our manufacturing processes and our reliance on third parties

fluctuations in our operating results, our ability to protect our

intellectual property rights and the cost of doing so, the risks of

doing business internationally and the other risks and uncertainties

that are described in Item 1.A. Risk Factors in our reports on Form 10-K

and Form 10-Q and in other periodic and current reports we file with the

SEC. These forward-looking statements speak only as of the date of this

letter, and we do not undertake any obligation to publicly update any

forward-looking statements, whether as a result of new information

future events, or otherwise.
Important Information
On May 8, 2008, Biogen Idec filed a definitive proxy statement with the

Securities and Exchange Commission (the "SEC")

in connection with the Company´s 2008 Annual

Meeting. Biogen Idec´s stockholders are

strongly advised to read the definitive proxy statement carefully before

making any voting or investment decision because the definitive proxy

statement contains important information. The Company´s

proxy statement and any other materials filed by the Company with the

SEC can be obtained free of charge at the SEC´s

web site at www.sec.gov or from Biogen Idec at http://investor.biogenidec.com.

The Company´s definitive proxy statement and

other materials will also be available for free by writing to Biogen

Idec Inc., 14 Cambridge Center, Cambridge, MA 02142 or by contacting our

proxy solicitor, Innisfree M&A Incorporated, by toll-free telephone at

(877) 750-5836.
Non-GAAP Information
GAAP financial presentations include significant purchase accounting

charges in 2003 and subsequent periods. Accordingly, we provide a "Ëœnon-GAAP´ perspective that removes these merger-related accounting impacts as well

as other charges. Our non-GAAP financial measures are defined as

reported, or GAAP, excluding (1) purchase accounting and merger-related

adjustments, (2) stock option expense and the cumulative effect of an

accounting change relating to the initial adoption of SFAS No. 123R and

(3) other items. We believe it is important to share these non-GAAP

financial measures with shareholders as they: better represent the

ongoing economics of the business, reflect how we manage the business

internally and set operational goals, and form the basis of our

management incentive programs. Accordingly, we believe investors´ understanding of the Company´s financial

performance is enhanced as a result of our disclosing these non-GAAP

financial measures. Non-GAAP net income and diluted EPS should not be

viewed in isolation or as a substitute for reported, or GAAP, net income

and diluted EPS.
GAAP EPS Reconciliation for 2010 Goals On a reported basis

calculated in accordance with accounting principles generally accepted

in the U.S. (GAAP), the Company aims to grow GAAP EPS from 2007 through

2010 at a 25% CAGR. The long-term non-GAAP EPS goal excludes the impact

of purchase accounting, merger-related adjustments, stock option

expense, and their related tax effects. In order to reconcile long-term

GAAP and non-GAAP EPS figures, the Company has excluded the following

items for 2008 through 2010 from our non-GAAP EPS goal provided above:

Purchase accounting charges, including amortization of acquired

intangible assets and IPR&D, is estimated to be $760-$800 million for

already completed transactions;

Stock option expense due to FAS 123R is estimated to be in the range

of $80-$90 million;

Tax benefit of $220-$240 million related to the pre-tax reconciling

items.

Because the Company cannot predict with certainty the nature or the

amount of non-operating or unusual charges through 2010, it has made no

assumption regarding new purchase accounting charges in this GAAP EPS

goal. The Company may incur charges or realize income through 2010 which

could cause actual results to vary from the goal.
GAAP EPS Reconciliation for 2008 Guidance

Non-GAAP diluted EPS in the range of $3.25-$3.45 representing growth

consistent with the Company´s stated goal of achieving 20% non-GAAP

EPS compound annual growth through 2010.

GAAP diluted EPS in the range of $2.28-$2.48.

In order to reconcile the 2008 GAAP and non-GAAP EPS guidance, we have

excluded the following items from non-GAAP diluted EPS guidance

provided above:

- Purchase accounting charges, including amortization of acquired

intangible assets and IPR&D, are estimated to be $340 million pre-tax

or approximately $0.92 per diluted share after-tax, for already

completed transactions;

- Stock option expense due to SFAS 123R in 2008 is estimated to be

approximately $20 million pre-tax (including approximately $4 million

in R&D and approximately $16 million in SG&A), or approximately $0.05

per diluted share after-tax.

Since the Company cannot predict with certainty the nature or the amount

of non-operating or unusual charges for 2008, we have made no

assumptions regarding other such charges in this GAAP guidance. The

Company may incur charges or realize gains in 2008 that could cause

actual results to vary from this guidance.
GAAP Net Income and EPS Reconciliation for 2003-2007 The

reconciliation between GAAP and non-GAAP net income and diluted EPS for

the years 2003 through 2007 can be found in the table below and is taken

from Annual Reports, 10-K filings and earnings press releases (FY

2003-2007).

= = = = = = = = = = =

Three Months Ended March 31, 2008
- - - - - -

EARNINGS PER SHARE

2008

2007
- - - - - -

- - - - - -

GAAP earnings per share - Diluted

$
0.54

$
0.38

- - - - - -

Adjustment to net income (as detailed below)

0.29

0.21

- - - - - -

Non-GAAP earnings per share - Diluted

$
0.83

$
0.59

- - - - - -

- - - - - -

- - - - - -

An itemized reconciliation between net income on a GAAP basis and

net income on a non-GAAP basis is as follows (in millions):
- - - - - -

- - - - - -

GAAP net income

$
163.1

$
131.5

- - - - - -

Adjustments:

- - - - - -

R&D: Stock option expense

2.7

3.0

- - - - - -

R&D: FIN 46 consolidations of Cardiokine and Neurimmune

0.8

-

- - - - - -

SG&A: Restructuring

-

0.1

- - - - - -

SG&A: Stock option expense

3.1

6.1

- - - - - -

Amortization of acquired intangible assets

74.8

59.9

- - - - - -

In-process research and development related to the contingent

consideration payment in 2008 associated with Conforma acquisition

and the acquisition of Syntonix in 2007

25.0

18.4

- - - - - -

Other income, net: FIN 46 consolidations of Cardiokine and Neurimmune

(0.8
)

-

- - - - - -

Income taxes: Income tax effect of reconciling items

(18.4
)

(16.6
)
- - - - - -

- - - - - -

Non-GAAP net income

$
250.3

$
202.4

- - - - - -

*The GAAP figures reflect: 2004-2007 "“ the

combined Biogen Idec; 2003 "“ a full year of

IDEC Pharmaceuticals and 7 weeks of the former Biogen, Inc. (for the

period 11/13/03 through 12/31/03). Numbers may not foot due to rounding.
GAAP Net Income EPS Reconciliation for Q1 2008 The reconciliation

between GAAP and non-GAAP net income and diluted EPS for the first

quarter of 2008 can be found in the table below and is taken from Annual

Reports, 10-K filings and earnings press releases.

= = = = = = = = = = =

Condensed Consolidated Statements of Income "“ Operating Basis

FY 2003

FY 2004

FY 2005

FY 2006

FY 2007
- - - - - -

GAAP diluted EPS

(4.92
)

0.07

0.47

0.63

1.99

- - - - - -

Adjustment to net income (see below)

6.14

1.38

1.10

1.62

0.75

- - - - - -

Effect of FAS128 and ETIF 0306

-

(0.05
)

-

-

-

- - - - - -

Non-GAAP diluted EPS

1.22

1.40

1.57

2.25

2.74

- - - - - -

GAAP Net Income ($M)

(875.1
)

25.1

160.7

217.5

638.2

- - - - - -

Revenue "“ Pre-merger Biogen product

royalty and corporate partner revenue

1,173.1

-

-

-

-

- - - - - -

COGS "“ Fair value step up of inventory

acquired from Biogen and Fumapharm

231.6

295.5

34.2

7.8

-

- - - - - -

COGS "“ Pre-merger Biogen cost of sales

(179.2
)

-

-

-

-

- - - - - -

COGS "“ Royalties related to Corixa

1.8

-

-

-

-

- - - - - -

COGS "“ Amevive divesture

-

-

36.4

-

-

- - - - - -

R&D "“ Pre-merger Biogen net R&D

(301.1
)

-

-

-

-

- - - - - -

R&D "“ Severance and restructuring

-

3.1

20.3

0.3

1.2

- - - - - -

R&D "“ Sale of plant

-

-

1.9

-

-

- - - - - -

SG&A "“ Pre-merger Biogen SG&A

(346.7
)

-

-

-

-

- - - - - -

SG&A "“ Merger related and purchase

accounting costs

-

-

-

0.1

-

- - - - - -

SG&A "“ Severance and restructuring

13.2

9.3

19.3

2.0

0.6

- - - - - -

Amortization of intangible assets primarily related to Biogen merger

33.2

347.7

302.3

267.0

257.5

- - - - - -

In-process R&D related to the Biogen Idec merger, acquisitions of

Conforma, Syntonix, and Fumapharm, and consolidation of Cardiokine

Neurimmune and Escoubloc

823.0

-

-

330.5

84.2

- - - - - -

Loss/(gain) on settlement of license agreements with Fumedica and

Fumapharm

-

-

-

(6.1
)

-

- - - - - -

(Gain)/loss on sale of long lived assets

-

-

111.8

(16.5
)

(0.4
)
- - - - - -

Other income, net: Pre-merger Biogen

32.9

-

-

-

-

- - - - - -

Other income, net: Consolidation of Cardiokine and Neurimmune and

gain on sale of long lived assets

-

-

-

-

(72.3
)
- - - - - -

Write down of investments

-

12.7

-

-

-

- - - - - -

Charitable donations and legal settlements

30.7

-

-

-

-

- - - - - -

Income taxes "“ Effect of reconciling items

(205.8
)

(195.4
)

(145.2
)

(70.3
)

(65.5
)
- - - - - -

Stock option expense

-

-

-

44.5

35.6

- - - - - -

Non-GAAP Net Income

431.7

498.0

541.7

776.8

879.1

- - - - - -

About Biogen IdecBiogen Idec creates new standards of care in

therapeutic areas with high unmet medical needs. Founded in 1978, Biogen

Idec is a global leader in the discovery, development, manufacturing

and commercialization of innovative therapies. Patients in more than 90

countries benefit from Biogen Idec´s significant products that address

diseases such as lymphoma, multiple sclerosis, and rheumatoid arthritis.

For product labeling, press releases and additional information about

the company, please visit www.biogenidec.com.1

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