The Medicines Company Reports Second Quarter and First Half 2008 Financial Results and Raises Full Year Top Line Guidance

The Medicines Company (NASDAQ: MDCO) today announced its financial results for the second quarter and first half of 2008.

Financial highlights for the second quarter of 2008:

• Net revenue increased by 54% to $86.7 million for the second quarter of 2008 from $56.4 million for the second quarter of 2007.
  • Angiomax® (bivalirudin) U.S. sales increased by 53% to $84.5 million for the second quarter of 2008 from $55.2 million for the second quarter of 2007.
  • Angiomax/Angiox international net revenue in the second quarter of 2008 increased $1.0 million to $2.2 million compared to $1.2 million in the second quarter of 2007.

• Net income for the second quarter of 2008 was $4.1 million, or $0.08 per share, compared to net income of $0.8 million, or $0.02 per share, for the second quarter of 2007.

• Excluding stock–based compensation expense and non–cash income taxes, the Company reported second quarter of 2008 non–GAAP net income of $14.5 million, or $0.28 per share, compared to non–GAAP net income of $5.1 million, or $0.10 per share, for the second quarter of 2007.

John Kelley, President and Chief Operating Officer, stated, "We continue to execute our Angiomax strategy to gain market share and further penetrate the PCI market. We look forward to hearing from the FDA on our Cleviprex submission and continue to build our European infrastructure which will lead to multiple revenue sources in the near future."

Financial highlights for the first half of 2008:

• Net revenue increased by 35% to $166.2 million for the first half of 2008 from $123.0 million for the same period in 2007.
  • Angiomax U.S. sales increased by 33% to $161.4 million for the first half of 2008 from $121.5 million for the first half of 2007.
  • Angiomax/Angiox international net revenue in the first half of 2008 increased $3.3 million to $4.8 million compared to $1.5 million in the first half of 2007.

• Net income for the first half of 2008 was $8.9 million, or $0.17 per share, compared to net income of $3.9 million, or $0.07 per share, for the first half of 2007.

• Excluding stock–based compensation expense and non–cash income taxes, the Company reported first half of 2008 non–GAAP net income of $26.9 million, or $0.51 per share, compared to non–GAAP net income of $13.3 million, or $0.25 per share, for the first half of 2007.

The following table provides reconciliations between GAAP and non–GAAP net income for the second quarter (Q2) and first half (1H) of 2008 and 2007. Non–GAAP net income excludes stock–based compensation expense and the non–cash provision for income taxes:

Note: Amounts may not sum due to rounding.

1Excluding stock–based compensation expense and the non–cash provision for income taxes

Reconciliations between GAAP and non–GAAP fully diluted earnings per share (EPS) for the second quarter (Q2) and first half (1H) of 2008 and 2007 are provided in the following table:

Note: Amounts may not sum due to rounding.

1Excluding stock–based compensation expense and the non–cash provision for income taxes

The Company believes that presenting the non–GAAP information contained in the financial tables and in this press release assists investors and others in gaining a better understanding of the Company´s core operating results and future prospects, expected growth rates or forecasted guidance, particularly as related to stock–based compensation expense and the non–cash provision for income taxes. Management uses this non–GAAP information, in addition to the GAAP information, as the basis for measuring the Company´s core operating performance and comparing such performance to that of prior periods and to the performance of its competitors. Such measures are also used by management in its financial and operating decision–making. Non–GAAP information is not meant to be considered superior to or a substitute for the Company´s results of operations prepared in accordance with GAAP. A reconciliation of GAAP results with non–GAAP results may also be found in the attached financial tables.

Revised 2008 Guidance

Based upon results of the first half of 2008, the Company provided revised 2008 guidance as follows:

• Full year net revenue of $335 million to $355 million, including:
  • U.S. net revenue for Angiomax of $320 million to $330 million
• SG&A expense of $153 million to $159 million (GAAP)
  • $135 million to $140 million excluding stock–based compensation expense
• Total stock–based compensation expense of $22 million to $24 million

The Company reaffirmed 2008 guidance on other line items as follows:

per share amounts)

(1) Note that GAAP reporting of R&D and SG&A include stock based compensation expense

There will be a conference call with management today at 8:30 a.m. Eastern Time to discuss second quarter and first half 2008 financial results, guidance and operational developments. The conference call will be available via phone and webcast. The webcast can be accessed at The Medicines Company website at www.themedicinescompany.com.

Replay is available from 11:30 a.m. Eastern Time following the conference call through August 6, 2008. To hear a replay of the call, dial 888–203–1112 (domestic) and 719–457–0820 (international). Passcode for both dial in numbers is 4642411.

MDCO–F

About The Medicines Company: The Medicines Company (NASDAQ: MDCO) is focused on advancing the treatment of critical care patients through the delivery of innovative, cost–effective medicines to the worldwide hospital marketplace. The Company markets Angiomax® (bivalirudin) in the United States and other countries for use in patients undergoing coronary angioplasty, a procedure to clear restricted blood flow in arteries around the heart. The Company also has two products in late–stage development, Cleviprex TM (clevidipine butyrate) injectable emulsion and cangrelor. The Company´s website is www.themedicinescompany.com.

This document is intended to assist listeners of The Medicines Company´s quarterly results conference call available via webcast at www.themedicinescompany.com. In this document and the call, statements about The Medicines Company that are not purely historical, and all other statements that are not purely historical, may be deemed to be forward–looking statements for purposes of the safe harbor provisions under The Private Securities Litigation Reform Act of 1995. Without limiting the foregoing, the words "believes," "anticipates" and "expects" and similar expressions, including our 2008 guidance, are intended to identify forward–looking statements. These forward–looking statements involve known and unknown risks and uncertainties that may cause the Company´s actual results, levels of activity, performance or achievements to be materially different from those expressed or implied by these forward–looking statements. Important factors that may cause or contribute to such differences include the extent of the commercial success of Angiomax, whether the Company´s products will advance in the clinical trials process on a timely basis or at all, whether the Company will make regulatory submissions for product candidates on a timely basis, whether its regulatory submissions will receive approvals from regulatory agencies on a timely basis or at all, whether physicians, patients and other key decision makers will accept clinical trial results, risks associated with the establishment of international operations, and such other factors as are set forth in the risk factors detailed from time to time in the Company´s periodic reports and registration statements filed with the Securities and Exchange Commission including, without limitation, the risk factors detailed in the Company´s Quarterly Report on Form 10–Q filed on May 12, 2008, which are incorporated herein by reference. The Company specifically disclaims any obligation to update these forward–looking statements.

(in thousands, except per share data)