Tripos Introduces Surflex-Dock Virtual Screening Software; Software Combines Unparalleled Enrichment with State-of-the-Art Speed, Accuracy and Usability

Tripos, Inc. (Nasdaq: TRPS), a leading provider of drug
discovery informatics products and chemistry research, today announced
the release of Surflex-Dock, a fully automatic flexible molecular
docking algorithm providing a significant leap forward in rapid
in-silico drug-screening applications.
The Surflex-Dock program, developed by Professor Ajay Jain, Ph.D.,
a faculty member at the University of California San Francisco Cancer
Research Institute, is proved to offer unparalleled enrichments in
virtual high-throughput screening, while exceeding the speed, accuracy
and usability provided by existing methods.
"Surflex-Dock couples a unique scoring function with a patented
search engine," Jain said. "This combination has been shown to yield
excellent results in terms of docking accuracy, and distinctively
superior results in terms of screening enrichment, compared with
existing methods."
Surflex-Dock has been extensively validated and favorably compared
with all leading competing methods by independent researchers
(Kellenberger, et al., Proteins: Structure, Function, and
Bioinformatics 57, 225-242 (2004)). Surflex-Dock is now fully
integrated into Tripos' market-leading SYBYL(R) molecular modeling
environment, and is available for immediate release.
"This announcement demonstrates Tripos' continuing commitment to
invest in novel technologies and the highest quality science in the
area of protein-ligand interactions," said Bryan Koontz, senior vice
president and general manager of Discovery Informatics at Tripos.
Those wanting more information about Surflex-Dock and how to
assess its impact on their high-throughput screening projects at no
charge should visit http://www.tripos.com/surflex, or contact their
local Tripos sales representative.

About Tripos, Inc.

Tripos (Nasdaq:TRPS) combines leading-edge technology and
innovative science to deliver consistently superior chemistry-research
products and services for the biotechnology, pharmaceutical and other
life science industries. Within Tripos' Discovery Informatics (DI)
business, the company provides software products and consulting
services to develop, manage, analyze and share critical drug discovery
information. Within Tripos' Discovery Research (DR) business, Tripos'
medicinal chemists and research scientists partner directly with
clients in their research initiatives, leveraging state-of-the-art
information technologies and research facilities. Headquartered in St.
Louis, Mo., Tripos spans the world with global research operations and
an international client base. Further information on Tripos can be
found at http://www.tripos.com.

Tripos and the Tripos logo are registered trademarks of Tripos,
Inc., and/or its affiliates in the United States and certain other
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