Aptuit Acquisition of Evotec AG CPD Business Completes Unique Global API Development Supply Chain



    Aptuit, Inc. today announced that it has completed the acquisition
    of the Chemical and Pharmaceutical Development (CPD) business of
    Evotec, which integrates an active pharmaceutical ingredient (API)
    facility in Oxford, England and a well-established and
    recently-expanded parenteral (injectable vials) fill/finish facility
    in Glasgow, Scotland into Aptuit´s global network. The integration of
    these development and small scale manufacturing facilities in Europe
    completes a unique global API supply chain where small scale
    development takes place in the US and Europe with commercial scale
    undertaken in new state of the art facilities in India. Aptuit brings
    this service to its current client base of more than 750
    pharmaceutical innovators.

    "Over the past 18 months we´ve assembled by strategic acquisitions
    the core competencies that are key to reducing the time and cost
    burdens of drug development for our customers, and that also build on
    our commitment to operate an efficient, integrated global network.
    This particular acquisition is an important building block for Aptuit
    as we move toward completing that network," said Michael A. Griffith,
    Chief Executive Officer and Founder of Aptuit. "As the overall life
    science industry evolves, we are continuously evaluating the ways in
    which the drug development process must change and improve, and
    executing forward-looking deals and partnerships that are beneficial
    to our customers now and for the life of their products."

    Griffith continued, "The commitment to be a global force and
    provide full service in the US, Europe and Asia requires foresight and
    discipline in anticipating the needs of the market, the ability to
    attract, train and retain talent and build an infrastructure that best
    meets those needs of our many and diverse clients continues to be the
    focus of our attention as we constantly strive for improvements in the
    drug development process. We also recognize that technology and the
    ability to capture, store, analyze and present data in paperless
    business transactions will be a prerequisite for companies like ours
    in the future and we continue to actively invest in those resources
    across our network.

    In addition, Paul McGee (formerly Evotec´s Senior Vice President
    of Chemical Development in Oxford, England), who will head the
    business in Oxford commented, "I am truly impressed by the positive
    response and interest by existing and prospective clients in the
    capabilities Aptuit is assembling to improve the drug development
    process and we have already made several proposals to clients jointly
    with other parts of the Aptuit network and I am also delighted to
    continue working on the exciting portfolio of products Evotec is
    developing through the long term supply agreement established between
    the two companies."

    Since the acquisition of Evotec´s CPD business was announced,
    Aptuit has worked to align:

    -- The CPD business with its existing solid-state chemistry,
    formulation and drug product manufacturing businesses, with a
    critical part of which is Aptuit´s solid-state chemistry
    center of excellence in West Lafayette (Indiana);

    -- The small molecule API development labs, kilo labs and pilot
    plants in Europe into Aptuit´s global API network with
    existing operations in Harrisonville (Missouri), Kansas City
    (Missouri) and Hyderabad (India), positioning Aptuit to
    provide drug substance development, scale-up and manufacturing
    capabilities in all three major pharmaceutical geographies;
    and

    -- The CPD business´ clinical scale parenteral fill/finish,
    including two lyophilization suites, with Aptuit´s existing
    fill/finish and lyophilization capabilities in Kansas City,
    establishing substantial capacity in one of the fastest
    growing and most lively sectors of drug development.

    "Positioning our Chemical and Pharmaceutical Development business
    supports the needs of our biotechnology and pharmaceutical innovator
    clients in this sector by giving them access to a mature suite of
    capabilities within a company that can support specific needs across
    the drug development continuum," said Jorn Aldag, President & Chief
    Executive Officer of Evotec.

    About Evotec

    Evotec is a leader in the discovery and development of novel small
    molecule drugs. Both through its own discovery programs and through
    research collaborations, the Company is generating the highest quality
    research results to its partners in the pharmaceutical and
    biotechnology industries.

    In proprietary projects, Evotec specializes in finding new
    treatments for diseases of the Central Nervous System. Evotec has
    three programs in clinical development: EVT 201, a partial positive
    allosteric modulator (pPAM) of the GABA(A) receptor complex for the
    treatment of insomnia, EVT 101, a subtype selective NMDA receptor
    antagonist for the treatment of Alzheimer´s disease and/or pain, and
    EVT 302, a MAO-B inhibitor in development for smoking cessation.

    www.evotec.com

    About Aptuit

    Aptuit is a global company focused on streamlining and supporting
    the drug development process for biotechnology and pharmaceutical
    innovators. The company was founded by a group of industry experts
    with extensive market experience who have a track record of building a
    similar, highly successful company through acquisitions and
    investment. Aptuit provides a comprehensive suite of product
    development services and competencies to more than 600 biotechnology
    and large, fully integrated pharmaceutical innovators worldwide.
    Following the acquisition of the CPD business, Aptuit will have 2,680
    employees across 18 global facilities, including the
    recently-announced formation of Aptuit Laurus (India). Aptuit´s
    mission is to engineer a better drug development process, and is
    partnered with Welsh, Carson, Anderson & Stowe, one of the world´s
    largest private equity investors. For more information about Aptuit,
    please visit www.aptuit.com.