UCB and Biogen Idec's Oral VLA-4 Antagonist Enters Phase II Development for Multiple Sclerosis



    UCB (Euronext Brussels: UCB) and Biogen Idec (NASDAQ: BIIB) today
    announced the initiation of a Phase II study of CDP323 - an oral VLA-4
    antagonist - under development for relapsing-remitting multiple
    sclerosis (MS). The double-blind, randomized Phase II study commenced
    this week with dosing of the first patient. The study is designed to
    enroll over 200 patients with relapsing-remitting MS who have failed
    earlier treatment with a beta-interferon. Last October the companies
    entered an agreement to co-develop and co-commercialize this small
    molecule compound.

    The trial compares the safety and efficacy of two doses of CDP323
    monotherapy to placebo over a period of six months. This is the first
    time that patients with MS will be exposed to CDP323. Approximately 50
    medical centers in Europe and the U.S. are expected to participate in
    this study. The results of this Phase II study are expected by the end
    of 2008.

    "Multiple sclerosis affects more than a million people worldwide
    and so far, no oral treatment has been available. An oral therapy
    would represent a significant advance for patients as it could provide
    them with a new, non-invasive option of drug delivery," said Professor
    Chris Polman, Professor of Neurology, VU Medical Centre, Amsterdam,
    the Netherlands, Lead Investigator for this study.

    About CDP323

    CDP323 is an orally active small molecule VLA-4 antagonist. The
    safety, tolerability and pharmacokinetic profile of CDP323 have been
    evaluated in healthy volunteers in three separate Phase I studies.
    Data from these studies were reported at the 2006 European Committee
    for Treatment and Research in Multiple Sclerosis (ECTRIMS). The data
    from these early studies supports further development of CDP323.

    About Multiple Sclerosis

    MS is a chronic disease of the central nervous system that affects
    approximately 400,000 people in North America and more than one
    million people worldwide. It is a disease that affects more women than
    men, with onset typically occurring between 20 and 50 years of age. MS
    is caused by damage to myelin, the protective sheath surrounding nerve
    fibers in the central nervous system, which interferes with messages
    from the brain to the body. Symptoms of MS may include vision
    problems, loss of balance, numbness, difficulty walking and paralysis.

    About UCB

    UCB (www.ucb-group.com) is a leading global biopharmaceutical
    company dedicated to the research, development and commercialisation
    of innovative pharmaceutical and biotechnology products in the fields
    of central nervous system disorders, allergy/respiratory diseases,
    immune and inflammatory disorders and oncology. UCB focuses on
    securing a leading position in severe disease categories. Employing
    over 8,500 people in over 40 countries, UCB achieved revenue of 2.5
    billion euro in 2006. UCB is listed on the Euronext Brussels Exchange
    and its worldwide headquarters are located in Brussels, Belgium.

    About Biogen Idec

    Biogen Idec creates new standards of care in therapeutic areas
    with high unmet medical needs. Founded in 1978, Biogen Idec is a
    global leader in the discovery, development, manufacturing, and
    commercialization of innovative therapies. Patients in more than 90
    countries benefit from Biogen Idec's significant products that address
    diseases such as lymphoma, multiple sclerosis, and rheumatoid
    arthritis. For product labeling, press releases and additional
    information about the company, please visit www.biogenidec.com.

    UCB and Biogen Idec Safe Harbor

    This press release contains forward-looking statements regarding
    the development of CDP323. Drug development involves a high degree of
    risk. Only a small number of research and development programs result
    in commercialization of a product. Factors which could cause actual
    results to differ materially from UCB's and Biogen Idec's current
    expectations include the risk that the companies may not be able to
    demonstrate the safety and efficacy of CDP323 at each stage of the
    clinical trial process; technical hurdles relating to the manufacture
    of CDP323 may be encountered; applicable regulatory standards may not
    be met or regulatory authorities may fail to approve CDP323; and other
    unexpected hurdles may be encountered.

    For more detailed information on the risks and uncertainties
    associated with Biogen Idec's drug development activities, see the
    section entitled "Risk Factors" in Biogen Idec's quarterly report on
    Form 10-Q for the fiscal quarter ended March 31, 2007 which was filed
    with the Securities and Exchange Commission, as well as other periodic
    and current reports of Biogen Idec filed with the Securities and
    Exchange Commission. Biogen Idec assumes no obligation to update any
    forward-looking statements, whether as a result of new information,
    future events or otherwise.