CyDex Announces Captisol Technology Used in Injection Formulation of Veterinary Anti-Emetic Cerenia(R) (Maropitant) Recently Approved for Marketing in Europe



    CyDex, Inc., a specialty pharmaceutical company developing
    improved products through innovative drug delivery, today announced
    that a subcutaneous injection formulation of the veterinary
    anti-emetic medication Cerenia(R) (maropitant) from Pfizer Limited
    contains CyDex's Captisol(R)-enabling technology.

    On September 29, 2006, the European Medicines Agency approved both
    the subcutaneous injection and tablet formulations of Pfizer's Cerenia
    for marketing throughout the European Union. Cerenia for Injection is
    used in dogs to prevent vomiting and treat vomiting such as that
    caused by chemotherapy.

    Cerenia for Injection is the fourth drug formulation utilizing
    Captisol to receive marketing approval. The other three
    Captisol-enabled drugs currently are commercially available. These
    include Geodon IM and Vfend IV, marketed globally by Pfizer Inc., and
    ABILIFY Injection marketed in the United States by Bristol-Myers
    Squibb and Otsuka Pharmaceutical Co.

    CyDex's patented Captisol technology improves water solubility,
    bioavailability and complexation characteristics of insoluble and/or
    unstable drugs. In addition to injectable products, the CyDex pipeline
    of licensed and proprietary Captisol-enabled formulations targets a
    range of market segments including oral solutions and capsules,
    ophthalmic solutions, oral solids and inhalation.

    "Pfizer's launch of Cerenia for Injection further illustrates the
    power of Captisol as an agent for improving aqueous solubility and
    thus enabling new dosage forms that can both broaden and lengthen the
    sales revenue stream for new drugs," said CyDex Chief Executive
    Officer John M. Seibert. "CyDex's pharmaceutical industry partners
    recognize that Captisol can serve as a valuable tool for drug
    lifecycle management, and we are working toward additional product
    launches by an expanding roster of partners in future years."

    About CyDex, Inc.

    CyDex is a specialty pharmaceutical company developing proprietary
    products and licensing its Captisol(R)-enabling technology. CyDex is
    bringing important new medications to patients by developing its own
    pipeline of proprietary products with advanced drug delivery
    solutions, and by partnering with the world's leading pharmaceutical
    and biotechnology companies. In addition to Cerenia(R) for Injection,
    the commercially available pharmaceuticals enabled by Captisol include
    Geodon IM and Vfend IV, marketed globally by Pfizer Inc., and ABILIFY
    Injection marketed in the United States by Bristol-Myers Squibb and
    Otsuka Pharmaceutical Co., Ltd., CyDex has development agreements with
    Allergan, Inc.; Bristol-Myers Squibb; Daiichi Asubio Pharma Co., Ltd.,
    of Japan; Merck & Co., Inc.; Mitsubishi Corporation, of Japan; OSI
    Pharmaceuticals, Inc.; PTC Pharma AG, of Switzerland; TargeGen, Inc.;
    Taisho Pharmaceuticals of Japan and Teva Pharmaceutical Industries
    Ltd., of Israel. CyDex also has clinical use agreements with major
    pharma and biotech companies. CyDex is a privately held company
    located in suburban Kansas City. To learn more about the company,
    please visit www.cydexinc.com.

    Captisol and Captisol-enabled are registered trademarks of CyDex,
    Inc. Cerenia, Geodon IM and Vfend IV are registered trademarks of
    Pfizer Inc. ABILIFY is a registered trademark of Otsuka Pharmaceutical
    Co., Ltd.