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Covidien and University of New South Wales to Collaborate on the Development of Novel Imaging Agent

5/10/2007 - 10:55
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    NewSouth Innovations Pty Limited, the technology transfer arm of
    University of New South Wales (UNSW), and Covidien Ltd. (NYSE: COV,
    BSX: COV) today announced the signing of a license agreement to
    develop an innovative, radiolabeled molecular imaging agent for
    evaluating the efficacy of cancer treatments. This technology could
    assist oncologists in determining the effectiveness of treatment and
    the necessity for other therapeutic measures.

    Based in Sydney, Australia, UNSW is a leader in the field of adult
    cancer research with internationally recognized medical scientists.
    Covidien Imaging Solutions, which is based in St. Louis, Missouri
    (USA), is a leading provider of imaging products used by physicians to
    detect and diagnose various diseases.

    Under the exclusive, worldwide agreement, Covidien Imaging
    Solutions has product development and commercialization rights for
    this apoptosis technology, which was invented by Professor Philip
    Hogg, who is a co-director of the Lowy Cancer Research Centre. The
    family of small molecules developed by Professor Hogg is designed to
    bind to cancer cells undergoing apoptosis, or the process of cell
    death, as a result of chemotherapy treatment.

    "This discovery stems from more than 10 years of research focused
    on the design of molecular probes to study cellular processes," said
    Professor Hogg. "These molecules are uniquely designed to attach to
    proteins inside cells undergoing apoptosis driven by chemotherapy."

    This early-stage apoptosis detection technology could take many
    years to develop, but it has the potential for broad application
    across a wide array of solid tumor cancers. According to data from the
    World Health Organization's International Agency for Research on
    Cancer, there are approximately 11 million new cases of cancer
    worldwide each year. Along with helping doctors to assess therapeutic
    responses non-invasively, this apoptosis technology would support the
    movement toward personalized or targeted therapies based on a
    patient's specific needs.

    "This license agreement demonstrates Covidien's focus on
    technology that is intended to improve patient care," said Steve
    Hanley, President of Covidien Imaging Solutions. "Our goal is to
    diagnose diseases or disease processes as early as possible. Apoptosis
    imaging would assist physicians in personalizing a patient's treatment
    by reducing the time needed to gauge the effectiveness of therapy."

    In addition, pharmaceutical companies may use the apoptosis
    technology to evaluate new products for cancer treatment.
    Apoptosis-detecting imaging agents may also have applications outside
    of cancer, such as in neurological and cardiac disease following
    strokes and heart attacks.

    ABOUT COVIDIEN

    Covidien is a leading global healthcare products company that
    creates innovative medical solutions for better patient outcomes and
    delivers value through clinical leadership and excellence. Covidien
    manufactures, distributes and services a diverse range of
    industry-leading product lines, including Surgical Devices,
    Energy-Based Devices, Respiratory and Monitoring Solutions, Patient
    Care and Safety Products, Imaging Solutions, Pharmaceutical Products,
    Medical Supplies and Retail Products. With 2006 revenue of nearly $10
    billion, Covidien has more than 43,000 employees worldwide in 57
    countries, and its products are sold in over 130 countries. Please
    visit www.covidien.com to learn more about our business.

    ABOUT UNIVERSITY OF NEW SOUTH WALES

    The Sydney-based University of New South Wales (UNSW) is one of
    Australia's leading teaching and research universities. Ranked in the
    top 50 in the world, UNSW boasts close to 40,000 students and is
    recognized as a leader in the field of medical research.

    NewSouth Innovations Pty Limited (NSi), UNSW's technology transfer
    arm, specialises in transforming research and technology developed at
    UNSW into a successful venture or product. With more than 45 years'
    experience NSi evaluates research technologies, identifies appropriate
    collaboration opportunities and provides industry partners and
    investors with access to a wide range of technologies with broad
    commercial potential.

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